After completing his undergraduate studies in biochemistry, Simon-Pierre Gravel earned a Ph.D. focusing on the innate immune response in the context of chronic diseases at the Faculty of Pharmacy at the Université de Montréal, under the supervision of Marc Servant. He then pursued postdoctoral training at the Rosalind & Morris Goodman Cancer Institute, working in Julie St-Pierre’s team, where he developed expertise in cancer metabolism. During this period, he studied the mechanisms of action of biguanides and developed advanced approaches to metabolomics and isotope tracing applied to mitochondria. He also collaborated with L’Oréal Paris on the study of metabolic pathways involved in skin aging. Since opening his laboratory at the Faculty of Pharmacy, he has led a research program aimed at identifying new pharmaceutical targets and characterizing the links between cellular metabolism and the immune response in human skin, particularly in the context of melanoma and skin aging. He also contributes to collaborative projects focused on the development of therapeutic nucleic acids and azapeptides for the treatment of rare diseases and conditions associated with cellular stress. He oversees the master’s and doctoral programs in pharmaceutical sciences.
Cancer metabolism and signaling
Simon-Pierre Gravel and his team are studying the metabolic and immunological remodeling mechanisms associated with tumor progression, aging, and resistance to targeted therapies and immunotherapy. Their work aims to identify new therapeutic targets in order to develop strategies that exploit the metabolic and immune vulnerabilities of tumor cells.
Research topics
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Cancer Genomics and Epigenetics