52 results
A Human Cerebral Organoid Model of Neural Cell Transplantation.
Ibanez-Rios MI, Narlis M, Hammond CA, Knapp D
J Vis Exp
2023-07-21
;(
197
):.
DNA barcoded competitive clone-initiating cell analysis reveals novel features of metastatic growth in a cancer xenograft model.
Aalam SMM, Tang X, Song J, Ray U, Russell SJ, Weroha SJ, Bakkum-Gamez J, Shridhar V, Sherman ME, Eaves CJ, Knapp D, Kalari KR, Kannan N
NAR Cancer
2022-09-01
;4(
3
):zcac022.
DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells.
Michaels YS, Edgar JM, Major MC, Castle EL, Zimmerman C, Yin T, Hagner A, Lau C, Hsu HH, Ibañez-Rios MI, Durland LJ, Knapp D, Zandstra PW
Sci Adv
2022-08-26
;8(
34
):eabn5522.
Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs.
Lorzadeh A, Hammond C, Wang F, Knapp D, Wong JC, Zhu JYA, Cao Q, Heravi-Moussavi A, Carles A, Wong M, Sharafian Z, Steif J, Moksa M, Bilenky M, Lavoie PM, Eaves CJ, Hirst M
BMC Biol
2022-05-13
;20(
1
):104.
Harnessing tRNA for Processing Ability and Promoter Activity.
Knapp D, Fulga TA
Methods Mol Biol
2021-01-01
;2162:89-114.
A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients.
Sadanandam A, Bopp T, Dixit S, Knapp D, Emperumal CP, Vergidis P, Rajalingam K, Melcher A, Kannan N
Cell Death Discov
2020-12-08
;6(
1
):141.
Survey Says: “COVID-19 Lockdown Hits Young Faculty and Clinical Trials”.
Kent DG, Knapp D, Kannan N
Stem Cell Reports
2020-07-14
;15(
1
):1-5.
Altered microRNA expression links IL6 and TNF-induced inflammaging with myeloid malignancy in humans and mice.
Grants JM, Wegrzyn J, Hui T, O'Neill K, Shadbolt M, Knapp D, Parker J, Deng Y, Gopal A, Docking TR, Fuller M, Li J, Boldin M, Eaves CJ, Hirst M, Karsan A
Blood
2020-06-18
;135(
25
):2235-2251.
The miR-185/PAK6 Axis Predicts Therapy Response and Regulates Survival of Drug-Resistant Leukemic Stem Cells in CML.
Lin H, Rothe K, Chen M, Wu A, Babaian A, Yen R, Zeng J, Ruschmann J, Petriv OI, O'Neill K, Maetzig T, Knapp D, Nakamichi N, Brinkman R, Birol I, Forrest DL, Hansen C, Humphries KK, Eaves CJ, Jiang X
Blood
2020-04-09
;.
H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.
Godfrey L, Crump NT, O'Byrne S, Lau IJ, Rice S, Harman JR, Jackson T, Elliott N, Buck G, Connor C, Thorne R, Knapp D, Heidenreich O, Vyas P, Menendez P, Inglott S, Ancliff P, Geng H, Roberts I, Roy A, Milne TA
Leukemia
2020-04-03
;.
Replication timing alterations in leukemia affect clinically relevant chromosome domains.
Rivera-Mulia JC, Sasaki T, Trevilla-Garcia C, Nakamichi N, Knapp D, Hammond CA, Chang BH, Tyner JW, Devidas M, Zimmerman J, Klein KN, Somasundaram V, Druker BJ, Gruber TA, Koren A, Eaves CJ, Gilbert DM
Blood Adv
2019-11-12
;3(
21
):3201-3213.
Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs.
O'Byrne S, Elliott N, Rice S, Buck G, Fordham N, Garnett C, Godfrey L, Crump NT, Wright G, Inglott S, Hua P, Psaila B, Povinelli B, Knapp D, Agraz-Doblas A, Bueno C, Varela I, Bennett P, Koohy H, Watt SM, Karadimitris A, Mead AJ, Ancliff P, Vyas P, Menendez P, Milne TA, Roberts I, Roy A
Blood
2019-09-26
;134(
13
):1059-1071.
Addendum: Precise tuning of gene expression levels in mammalian cells.
Michaels YS, Barnkob MB, Barbosa H, Baeumler TA, Thompson MK, Andre V, Colin-York H, Fritzsche M, Gileadi U, Sheppard HM, Knapp D, Milne TA, Cerundolo V, Fulga TA
Nat Commun
2019-06-10
;10(
1
):2622.
Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression.
Knapp D, Michaels YS, Jamilly M, Ferry QRV, Barbosa H, Milne TA, Fulga TA
Nat Commun
2019-04-02
;10(
1
):1490.
A topological view of human CD34+ cell state trajectories from integrated single-cell output and proteomic data.
Knapp D, Hammond CA, Wang F, Aghaeepour N, Miller PH, Beer PA, Pellacani D, VanInsberghe M, Hansen C, Bendall SC, Nolan GP, Eaves CJ
Blood
2019-02-28
;133(
9
):927-939.
Precise tuning of gene expression levels in mammalian cells.
Michaels YS, Barnkob MB, Barbosa H, Baeumler TA, Thompson MK, Andre V, Colin-York H, Fritzsche M, Gileadi U, Sheppard HM, Knapp D, Milne TA, Cerundolo V, Fulga TA
Nat Commun
2019-02-18
;10(
1
):818.
Control of the hematopoietic stem cell state.
Knapp D, Eaves CJ
Cell Res.
2018-12-02
;24(
1
):3-4.
GateFinder: projection-based gating strategy optimization for flow and mass cytometry.
Aghaeepour N, Simonds EF, Knapp D, Bruggner RV, Sachs K, Culos A, Gherardini PF, Samusik N, Fragiadakis GK, Bendall SC, Gaudilliere B, Angst MS, Eaves CJ, Weiss WA, Fantl WJ, Nolan GP
Bioinformatics
2018-12-01
;34(
23
):4131-4133.
High-Resolution Single-Cell DNA Methylation Measurements Reveal Epigenetically Distinct Hematopoietic Stem Cell Subpopulations.
Hui T, Cao Q, Wegrzyn-Woltosz J, O'Neill K, Hammond CA, Knapp D, Laks E, Moksa M, Aparicio S, Eaves CJ, Karsan A, Hirst M
Stem Cell Reports
2018-08-14
;11(
2
):578-592.
UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells.
Ngom M, Imren S, Maetzig T, Adair JE, Knapp D, Chagraoui J, Fares I, Bordeleau ME, Sauvageau G, Leboulch P, Eaves C, Humphries RK
Mol Ther Methods Clin Dev
2018-07-05
;10:156-164.
Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential.
Knapp D, Hammond CA, Hui T, van Loenhout MTJ, Wang F, Aghaeepour N, Miller PH, Moksa M, Rabu GM, Beer PA, Pellacani D, Humphries RK, Hansen C, Hirst M, Eaves CJ
Nat. Cell Biol.
2018-06-01
;20(
6
):710-720.
A multiplexable TALE-based binary expression system for in vivo cellular interaction studies.
Toegel M, Azzam G, Lee EY, Knapp D, Tan Y, Fa M, Fulga TA
Nat Commun
2017-11-21
;8(
1
):1663.
Mass Cytometric Analysis Reveals Viable Activated Caspase-3+ Luminal Progenitors in the Normal Adult Human Mammary Gland.
Knapp D, Kannan N, Pellacani D, Eaves CJ
Cell Rep
2017-10-24
;21(
4
):1116-1126.
Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice.
Miller PH, Rabu G, MacAldaz M, Knapp D, Cheung AM, Dhillon K, Nakamichi N, Beer PA, Shultz LD, Humphries RK, Eaves CJ
Exp. Hematol.
2017-04-01
;48:41-49.
Distinct signaling programs control human hematopoietic stem cell survival and proliferation.
Knapp D, Hammond CA, Aghaeepour N, Miller PH, Pellacani D, Beer PA, Sachs K, Qiao W, Wang W, Humphries RK, Sauvageau G, Zandstra PW, Bendall SC, Nolan GP, Hansen C, Eaves CJ
Blood
2017-01-19
;129(
3
):307-318.
Dissociation of Survival, Proliferation, and State Control in Human Hematopoietic Stem Cells.
Knapp D, Hammond CA, Miller PH, Rabu GM, Beer PA, Ricicova M, Lecault V, Da Costa D, VanInsberghe M, Cheung AM, Pellacani D, Piret J, Hansen C, Eaves CJ
Stem Cell Reports
2017-01-10
;8(
1
):152-162.
Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks.
Pellacani D, Bilenky M, Kannan N, Heravi-Moussavi A, Knapp D, Gakkhar S, Moksa M, Carles A, Moore R, Mungall AJ, Marra MA, Jones SJM, Aparicio S, Hirst M, Eaves CJ
Cell Rep
2016-11-15
;17(
8
):2060-2074.
Nucleosome Density ChIP-Seq Identifies Distinct Chromatin Modification Signatures Associated with MNase Accessibility.
Lorzadeh A, Bilenky M, Hammond C, Knapp D, Li L, Miller PH, Carles A, Heravi-Moussavi A, Gakkhar S, Moksa M, Eaves CJ, Hirst M
Cell Rep
2016-11-15
;17(
8
):2112-2124.
Quantitation of Human Cells that Produce Neutrophils and Platelets in Vivo Obtained from Normal Donors Treated with Granulocyte Colony-Stimulating Factor and/or Plerixafor.
Miller PH, Nakamichi N, Knapp D, Rabu G, Schultz KR, Jones DM, Couban S, Eaves CJ
Biol. Blood Marrow Transplant.
2016-11-01
;22(
11
):1945-1952.
Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals.
Sawai CM, Babovic S, Upadhaya S, Knapp D, Lavin Y, Lau CM, Goloborodko A, Feng J, Fujisaki J, Ding L, Mirny LA, Merad M, Eaves CJ, Reizis B
Immunity
2016-09-20
;45(
3
):597-609.
Early production of human neutrophils and platelets posttransplant is severely compromised by growth factor exposure.
Miller PH, Knapp D, Beer PA, MacAldaz M, Rabu G, Cheung AM, Wei L, Eaves CJ
Exp. Hematol.
2016-07-01
;44(
7
):635-40.
Dominant-negative IKAROS enhances IL-3-stimulated signaling in wild-type but not BCR-ABL1(+) mouse BA/F3 cells.
von Palffy S, Bulaeva E, Babovic S, Kannan N, Knapp D, Wei L, Eaves CJ, Beer PA
Exp. Hematol.
2015-07-01
;43(
7
):514-23.e1-2.
Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression.
Beer PA, Knapp D, Miller PH, Kannan N, Sloma I, Heel K, Babovic S, Bulaeva E, Rabu G, Terry J, Druker BJ, Loriaux MM, Loeb KR, Radich JP, Erber WN, Eaves CJ
Blood
2015-01-15
;125(
3
):504-15.
DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts.
Nguyen LV, Cox CL, Eirew P, Knapp D, Pellacani D, Kannan N, Carles A, Moksa M, Balani S, Shah S, Hirst M, Aparicio S, Eaves CJ
Nat Commun
2014-12-23
;5:5871.
A dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells.
Beer PA, Knapp D, Kannan N, Miller PH, Babovic S, Bulaeva E, Aghaeepour N, Rabu G, Rostamirad S, Shih K, Wei L, Eaves CJ
Stem Cell Reports
2014-11-11
;3(
5
):841-57.
Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.
Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp D, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G
Science
2014-09-19
;345(
6203
):1509-12.
Distinct stromal cell factor combinations can separately control hematopoietic stem cell survival, proliferation, and self-renewal.
Wohrer S, Knapp D, Copley MR, Benz C, Kent DG, Rowe K, Babovic S, Mader H, Oostendorp RA, Eaves CJ
Cell Rep
2014-06-26
;7(
6
):1956-67.
“Deep” sequencing accuracy and reproducibility using Roche/454 technology for inferring co-receptor usage in HIV-1.
Knapp D, McGovern RA, Poon AF, Zhong X, Chan D, Swenson LC, Dong W, Harrigan PR
PLoS ONE
2014-06-24
;9(
6
):e99508.
Limited evolution of inferred HIV-1 tropism while viremia is undetectable during standard HAART therapy.
Lee GQ, Dong W, Mo T, Knapp D, Brumme CJ, Woods CK, Kanters S, Yip B, Harrigan PR
PLoS ONE
2014-06-06
;9(
6
):e99000.
Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice.
Cheung AM, Nguyen LV, Carles A, Beer P, Miller PH, Knapp D, Dhillon K, Hirst M, Eaves CJ
Blood
2013-10-31
;122(
18
):3129-37.
Developmental changes in the in vitro activated regenerative activity of primitive mammary epithelial cells.
Makarem M, Kannan N, Nguyen LV, Knapp D, Balani S, Prater MD, Stingl J, Raouf A, Nemirovsky O, Eirew P, Eaves CJ
PLoS Biol.
2013-08-13
;11(
8
):e1001630.
The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells.
Copley MR, Babovic S, Benz C, Knapp D, Beer PA, Kent DG, Wohrer S, Treloar DQ, Day C, Rowe K, Mader H, Kuchenbauer F, Humphries RK, Eaves CJ
Nat. Cell Biol.
2013-08-01
;15(
8
):916-25.
Heterogeneity in hematopoietic stem cell populations: implications for transplantation.
Miller PH, Knapp D, Eaves CJ
Curr. Opin. Hematol.
2013-07-01
;20(
4
):257-64.
Factors influencing the sensitivity and specificity of conventional sequencing in human immunodeficiency virus type 1 tropism testing.
Knapp D, McGovern RA, Dong W, Poon AF, Swenson LC, Zhong X, Woods CK, Harrigan PR
J. Clin. Microbiol.
2013-02-01
;51(
2
):444-51.
Enhanced normal short-term human myelopoiesis in mice engineered to express human-specific myeloid growth factors.
Miller PH, Cheung AM, Beer PA, Knapp D, Dhillon K, Rabu G, Rostamirad S, Humphries RK, Eaves CJ
Blood
2013-01-31
;121(
5
):e1-4.
Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1.
Carlson JM, Brumme CJ, Martin E, Listgarten J, Brockman MA, Le AQ, Chui CK, Cotton LA, Knapp D, Riddler SA, Haubrich R, Nelson G, Pfeifer N, Deziel CE, Heckerman D, Apps R, Carrington M, Mallal S, Harrigan PR, John M, Brumme ZL,
J. Virol.
2012-12-01
;86(
24
):13202-16.
Increasingly successful highly active antiretroviral therapy delays the emergence of new HLA class I-associated escape mutations in HIV-1.
Knapp D, Brumme ZL, Huang SY, Wynhoven B, Dong WW, Mo T, Harrigan PR, Brumme CJ
Clin. Infect. Dis.
2012-06-01
;54(
11
):1652-9.
Aldehyde dehydrogenase activity is a biomarker of primitive normal human mammary luminal cells.
Eirew P, Kannan N, Knapp D, Vaillant F, Emerman JT, Lindeman GJ, Visvader JE, Eaves CJ
Stem Cells
2012-02-01
;30(
2
):344-8.
Dates of HIV infection can be estimated for seroprevalent patients by coalescent analysis of serial next-generation sequencing data.
Poon AF, McGovern RA, Mo T, Knapp D, Brenner B, Routy JP, Wainberg MA, Harrigan PR
AIDS
2011-10-23
;25(
16
):2019-26.
Deep V3 sequencing for HIV type 1 tropism in treatment-naive patients: a reanalysis of the MERIT trial of maraviroc.
Swenson LC, Mo T, Dong WW, Zhong X, Woods CK, Thielen A, Jensen MA, Knapp D, Chapman D, Portsmouth S, Lewis M, James I, Heera J, Valdez H, Harrigan PR
Clin. Infect. Dis.
2011-10-01
;53(
7
):732-42.