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18 results


Publications — IRIC October 30, 2020

RAS GTPase signalling to alternative effector pathways.

Singh S, Smith M
Biochem Soc Trans 2020-10-30 ;48( 5 ):2241-2252.


Publications — IRIC October 13, 2020

RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway.

Dhanaraman T, Singh S, Killoran RC, Singh A, Xu X, Shifman JM, Smith M
Sci Signal 2020-10-13 ;13( 653 ):.


Publications — IRIC July 10, 2020

Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.

Chang L, Yang J, Jo CH, Boland A, Zhang Z, McLaughlin SH, Abu-Thuraia A, Killoran RC, Smith M, Côté JF, Barford D
Nat Commun 2020-07-10 ;11( 1 ):3464.


Publications — IRIC July 1, 2020

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization.

Cao L, Yonis A, Vaghela M, Barriga EH, Chugh P, Smith M, Maufront J, Lavoie G, Méant A, Ferber E, Bovellan M, Alberts A, Bertin A, Mayor R, Paluch EK, Roux PP, Jégou A, Romet-Lemonne G, Charras G
Nat. Cell Biol. 2020-07-01 ;22( 7 ):803-814.


Publications — IRIC June 21, 2019

Conformational resolution of nucleotide cycling and effector interactions for multiple small GTPases determined in parallel.

Killoran RC, Smith M
J. Biol. Chem. 2019-06-21 ;294( 25 ):9937-9948.


Publications — IRIC October 23, 2017

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.

Smith M, Ottoni E, Ishiyama N, Goudreault M, Haman A, Meyer C, Tucholska M, Gasmi-Seabrook G, Menezes S, Laister RC, Minden MD, Marschalek R, Gingras AC, Hoang T, Ikura M
Nat Commun 2017-10-23 ;8( 1 ):1099.


Publications — IRIC January 1, 2017

Inhibition of RAS function through targeting an allosteric regulatory site.

Smith M, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JP
Nat. Chem. Biol. 2017-01-01 ;13( 1 ):62-68.


Publications — IRIC July 22, 2016

Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).

Fang Z, Marshall CB, Yin JC, Mazhab-Jafari MT, Gasmi-Seabrook GM, Smith M, Nishikawa T, Xu Y, Neel BG, Ikura M
J. Biol. Chem. 2016-07-22 ;291( 30 ):15641-52.


Publications June 1, 2015

Real-time NMR monitoring of biological activities in complex physiological environments.

Smith M, Marshall CB, Theillet FX, Binolfi A, Selenko P, Ikura M
Curr. Opin. Struct. Biol. 2015-06-01 ;32:39-47.


Publications May 26, 2015

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.

Mazhab-Jafari MT, Marshall CB, Smith M, Gasmi-Seabrook GM, Stathopulos PB, Inagaki F, Kay LE, Neel BG, Ikura M
Proc. Natl. Acad. Sci. U.S.A. 2015-05-26 ;112( 21 ):6625-30.


Publications March 1, 2014

Integrated RAS signaling defined by parallel NMR detection of effectors and regulators.

Smith M, Ikura M
Nat. Chem. Biol. 2014-03-01 ;10( 3 ):223-30.


Publications October 4, 2013

A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues.

Long D, Marshall CB, Bouvignies G, Mazhab-Jafari MT, Smith M, Ikura M, Kay LE
Angew. Chem. Int. Ed. Engl. 2013-10-04 ;52( 41 ):10771-4.


Publications March 19, 2013

NMR-based functional profiling of RASopathies and oncogenic RAS mutations.

Smith M, Neel BG, Ikura M
Proc. Natl. Acad. Sci. U.S.A. 2013-03-19 ;110( 12 ):4574-9.


Publications February 28, 2013

Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.

Findlay GM, Smith M, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, Ikura M, Li SS, Sidhu SS, Rossant J, Pawson T
Cell 2013-02-28 ;152( 5 ):1008-20.


Publications August 1, 2012

Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts.

Marshall CB, Meiri D, Smith M, Mazhab-Jafari MT, Gasmi-Seabrook GM, Rottapel R, Stambolic V, Ikura M
Methods 2012-08-01 ;57( 4 ):473-85.


Publications April 2, 2010

Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion.

Ishiyama N, Lee SH, Liu S, Li GY, Smith M, Reichardt LF, Ikura M
Cell 2010-04-02 ;141( 1 ):117-28.


Publications March 3, 2010

The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1.

Smith M, Hardy WR, Li GY, Goudreault M, Hersch S, Metalnikov P, Starostine A, Pawson T, Ikura M
EMBO J. 2010-03-03 ;29( 5 ):884-96.


Publications February 19, 2010

Real-time NMR study of three small GTPases reveals that fluorescent 2’(3’)-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.

Mazhab-Jafari MT, Marshall CB, Smith M, Gasmi-Seabrook GM, Stambolic V, Rottapel R, Neel BG, Ikura M
J. Biol. Chem. 2010-02-19 ;285( 8 ):5132-6.

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Matthew Smith
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