19 results
NMR Detection Methods for Profiling RAS Nucleotide Cycling.
Killoran RC, Smith M
Methods Mol Biol
2021-05-12
;2262:169-182.
RAS GTPase signalling to alternative effector pathways.
Singh S, Smith M
Biochem Soc Trans
2020-10-30
;48(
5
):2241-2252.
RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway.
Dhanaraman T, Singh S, Killoran RC, Singh A, Xu X, Shifman JM, Smith M
Sci Signal
2020-10-13
;13(
653
):.
Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state.
Chang L, Yang J, Jo CH, Boland A, Zhang Z, McLaughlin SH, Abu-Thuraia A, Killoran RC, Smith M, Côté JF, Barford D
Nat Commun
2020-07-10
;11(
1
):3464.
SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization.
Cao L, Yonis A, Vaghela M, Barriga EH, Chugh P, Smith M, Maufront J, Lavoie G, Méant A, Ferber E, Bovellan M, Alberts A, Bertin A, Mayor R, Paluch EK, Roux PP, Jégou A, Romet-Lemonne G, Charras G
Nat. Cell Biol.
2020-07-01
;22(
7
):803-814.
Conformational resolution of nucleotide cycling and effector interactions for multiple small GTPases determined in parallel.
Killoran RC, Smith M
J. Biol. Chem.
2019-06-21
;294(
25
):9937-9948.
Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.
Smith M, Ottoni E, Ishiyama N, Goudreault M, Haman A, Meyer C, Tucholska M, Gasmi-Seabrook G, Menezes S, Laister RC, Minden MD, Marschalek R, Gingras AC, Hoang T, Ikura M
Nat Commun
2017-10-23
;8(
1
):1099.
Inhibition of RAS function through targeting an allosteric regulatory site.
Smith M, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JP
Nat. Chem. Biol.
2017-01-01
;13(
1
):62-68.
Biochemical Classification of Disease-associated Mutants of RAS-like Protein Expressed in Many Tissues (RIT1).
Fang Z, Marshall CB, Yin JC, Mazhab-Jafari MT, Gasmi-Seabrook GM, Smith M, Nishikawa T, Xu Y, Neel BG, Ikura M
J. Biol. Chem.
2016-07-22
;291(
30
):15641-52.
Real-time NMR monitoring of biological activities in complex physiological environments.
Smith M, Marshall CB, Theillet FX, Binolfi A, Selenko P, Ikura M
Curr. Opin. Struct. Biol.
2015-06-01
;32:39-47.
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.
Mazhab-Jafari MT, Marshall CB, Smith M, Gasmi-Seabrook GM, Stathopulos PB, Inagaki F, Kay LE, Neel BG, Ikura M
Proc. Natl. Acad. Sci. U.S.A.
2015-05-26
;112(
21
):6625-30.
Integrated RAS signaling defined by parallel NMR detection of effectors and regulators.
Smith M, Ikura M
Nat. Chem. Biol.
2014-03-01
;10(
3
):223-30.
A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues.
Long D, Marshall CB, Bouvignies G, Mazhab-Jafari MT, Smith M, Ikura M, Kay LE
Angew. Chem. Int. Ed. Engl.
2013-10-04
;52(
41
):10771-4.
NMR-based functional profiling of RASopathies and oncogenic RAS mutations.
Smith M, Neel BG, Ikura M
Proc. Natl. Acad. Sci. U.S.A.
2013-03-19
;110(
12
):4574-9.
Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.
Findlay GM, Smith M, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, Ikura M, Li SS, Sidhu SS, Rossant J, Pawson T
Cell
2013-02-28
;152(
5
):1008-20.
Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts.
Marshall CB, Meiri D, Smith M, Mazhab-Jafari MT, Gasmi-Seabrook GM, Rottapel R, Stambolic V, Ikura M
Methods
2012-08-01
;57(
4
):473-85.
Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion.
Ishiyama N, Lee SH, Liu S, Li GY, Smith M, Reichardt LF, Ikura M
Cell
2010-04-02
;141(
1
):117-28.
The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1.
Smith M, Hardy WR, Li GY, Goudreault M, Hersch S, Metalnikov P, Starostine A, Pawson T, Ikura M
EMBO J.
2010-03-03
;29(
5
):884-96.
Real-time NMR study of three small GTPases reveals that fluorescent 2’(3’)-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.
Mazhab-Jafari MT, Marshall CB, Smith M, Gasmi-Seabrook GM, Stambolic V, Rottapel R, Neel BG, Ikura M
J. Biol. Chem.
2010-02-19
;285(
8
):5132-6.