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92 results


Publications — IRIC juin 28, 2022

CEACAM1 is a novel culture-compatible surface marker of expanded long-term reconstituting hematopoietic stem cells.

Ansari U, Tomellini E, Chagraoui J, Lehnertz B, Mayotte N, Bordeleau ME, Roux PP, Sauvageau G
Blood Adv 2022-06-28 ;6( 12 ):3626-3631.


Publications — IRIC mars 22, 2022

Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation.

Heckel E, Cagnone G, Agnihotri T, Cakir B, Das A, Kim JS, Kim N, Lavoie G, Situ A, Pundir S, Sun Y, Wünnemann F, Pierce KA, Dennis C, Mitchell GA, Chemtob S, Rezende FA, Andelfinger G, Clish CB, Roux PP, Sapieha P, Smith LE, Joyal JS
JCI Insight 2022-03-22 ;7( 6 ):.


Publications — IRIC juin 1, 2021

RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit.

Cerezo EL, Houles T, Lié O, Sarthou MK, Audoynaud C, Lavoie G, Halladjian M, Cantaloube S, Froment C, Burlet-Schiltz O, Henry Y, Roux PP, Henras AK, Romeo Y
PLoS Genet 2021-06-01 ;17( 6 ):e1009583.


Publications — IRIC février 1, 2021

Sustained ERK1/2 signaling is necessary for follicular rupture during ovulation in mice.

Madogwe E, Schuermann Y, Siddappa D, Bordignon V, Roux PP, Duggavathi R
Reproduction 2021-02-01 ;161( 2 ):183-193.


Publications — IRIC novembre 2, 2020

STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity.

De Jamblinne CV, Decelle B, Dehghani M, Joseph M, Sriskandarajah N, Leguay K, Rambaud B, Lemieux S, Roux PP, Hipfner DR, Carréno S
J Cell Biol 2020-11-02 ;219( 11 ):.


Publications — IRIC octobre 7, 2020

Targeting copper metabolism to defeat KRAS-driven colorectal cancer.

Aubert L, Nandagopal N, Roux PP
Mol Cell Oncol 2020-10-07 ;7( 6 ):1822123.


Publications — IRIC août 18, 2020

An ErbB2 splice variant lacking exon 16 drives lung carcinoma.

Smith HW, Yang L, Ling C, Walsh A, Martinez VD, Boucher J, Zuo D, Sokol ES, Pavlick DC, Frampton GM, Chmielecki J, Jones LM, Roux PP, Lockwood WW, Muller WJ
Proc. Natl. Acad. Sci. U.S.A. 2020-08-18 ;117( 33 ):20139-20148.


Publications — IRIC juillet 24, 2020

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.

Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J, Saba-El-Leil MK, Papadopoli D, Lin S, Hart T, Macleod G, Topisirovic I, Gaboury L, Fahrni CJ, Schramek D, Meloche S, Angers S, Roux PP
Nat Commun 2020-07-24 ;11( 1 ):3701.


Publications — IRIC juillet 1, 2020

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization.

Cao L, Yonis A, Vaghela M, Barriga EH, Chugh P, Smith M, Maufront J, Lavoie G, Méant A, Ferber E, Bovellan M, Alberts A, Bertin A, Mayor R, Paluch EK, Roux PP, Jégou A, Romet-Lemonne G, Charras G
Nat. Cell Biol. 2020-07-01 ;22( 7 ):803-814.


Publications — IRIC mai 19, 2020

NF45 and NF90 Regulate Mitotic Gene Expression by Competing with Staufen-Mediated mRNA Decay.

Nourreddine S, Lavoie G, Paradis J, Ben El Kadhi K, Méant A, Aubert L, Grondin B, Gendron P, Chabot B, Bouvier M, Carréno S, Roux PP
Cell Rep 2020-05-19 ;31( 7 ):107660.


Publications — IRIC mai 15, 2020

Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling.

He Y, Zuo C, Jia D, Bai P, Kong D, Chen D, Liu G, Li J, Wang Y, Chen G, Yan S, Xiao B, Zhang J, Piao L, Li Y, Deng Y, Li B, Roux PP, Andreasson KI, Breyer RM, Su Y, Wang J, Lyu A, Shen Y, Yu Y
Am. J. Respir. Crit. Care Med. 2020-05-15 ;201( 10 ):1263-1276.


Publications — IRIC avril 17, 2020

Controversies around the function of LARP1.

Berman AJ, Thoreen CC, Dedeic Z, Chettle J, Roux PP, Blagden SP
RNA Biol 2020-04-17 ;1-11.


Publications — IRIC janvier 29, 2020

F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis.

Serres MP, Samwer M, Truong Quang BA, Lavoie G, Perera U, Görlich D, Charras G, Petronczki M, Roux PP, Paluch EK
Dev. Cell 2020-01-29 ;52( 2 ):210-222.e7.


Publications — IRIC janvier 2, 2020

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.

Méant A, Gao B, Lavoie G, Nourreddine S, Jung F, Aubert L, Tcherkezian J, Gingras AC, Roux PP
Mol. Cell Proteomics 2020-01-02 ;19( 1 ):50-64.


Publications — IRIC décembre 9, 2019

Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1.

Layoun A, Goldberg AA, Baig A, Eng M, Attias O, Nelson K, Carella A, Amberber N, Fielhaber JA, Joung KB, Martin Schmeing T, Han Y, Downey J, Divangahi M, Roux PP, Kristof AS
Sci Rep 2019-12-09 ;9( 1 ):17620.


Publications — IRIC novembre 12, 2019

Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities.

Cardin S, Bilodeau M, Roussy M, Aubert L, Milan T, Jouan L, Rouette A, Laramée L, Gendron P, Duchaine J, Decaluwe H, Spinella JF, Mourad S, Couture F, Sinnett D, Haddad E, Landry JR, Ma J, Humphries RK, Roux PP, Hébert J, Gruber TA, Wilhelm B, Cellot S
Blood Adv 2019-11-12 ;3( 21 ):3307-3321.


Publications — IRIC octobre 1, 2019

Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children.

de Smith AJ, Lavoie G, Walsh KM, Aujla S, Evans E, Hansen HM, Smirnov I, Kang AY, Zenker M, Ceremsak JJ, Stieglitz E, Muskens IS, Roberts W, McKean-Cowdin R, Metayer C, Roux PP, Wiemels JL
Genes Chromosomes Cancer 2019-10-01 ;58( 10 ):723-730.


Publications — IRIC septembre 2, 2019

Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration.

Plutoni C, Keil S, Zeledon C, Delsin LEA, Decelle B, Roux PP, Carréno S, Emery G
Nat Commun 2019-09-02 ;10( 1 ):3940.


Publications — IRIC juillet 8, 2019

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.

Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G
Cancer Cell 2019-07-08 ;36( 1 ):84-99.e8.


Publications — IRIC février 19, 2019

ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation.

Shin S, Buel GR, Nagiec MJ, Han MJ, Roux PP, Blenis J, Yoon SO
Proc. Natl. Acad. Sci. U.S.A. 2019-02-19 ;116( 8 ):2967-2976.


Publications — IRIC juin 15, 2018

Signaling Pathways Involved in the Regulation of mRNA Translation.

Roux PP, Topisirovic I
Mol. Cell. Biol. 2018-06-15 ;38( 12 ):.


Publications — IRIC mai 1, 2018

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.

Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JF
Cell Rep 2018-05-01 ;23( 5 ):1476-1490.


Publications — IRIC février 20, 2018

CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3β adaptor protein.

Ouadda ABD, He Y, Calabrese V, Ishii H, Chidiac R, Gratton JP, Roux PP, Lamarche-Vane N
Oncotarget 2018-02-20 ;9( 14 ):11646-11664.


Publications — IRIC février 15, 2018

RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma.

Houles T, Gravel SP, Lavoie G, Shin S, Savall M, Méant A, Grondin B, Gaboury L, Yoon SO, St-Pierre J, Roux PP
Cancer Res. 2018-02-15 ;.


Publications — IRIC juillet 13, 2017

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.

Yoon SO, Shin S, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP, Dephoure N, Blenis J
Mol. Cell 2017-07-13 ;.


Publications — IRIC juin 22, 2017

EPCR expression marks UM171-expanded CD34(+) cord blood stem cells.

Fares I, Chagraoui J, Lehnertz B, MacRae T, Mayotte N, Tomellini E, Aubert L, Roux PP, Sauvageau G
Blood 2017-06-22 ;129( 25 ):3344-3351.


Publications — IRIC mai 22, 2017

Actin cortex architecture regulates cell surface tension.

Chugh P, Clark AG, Smith MB, Cassani DAD, Dierkes K, Ragab A, Roux PP, Charras G, Salbreux G, Paluch EK
Nat. Cell Biol. 2017-05-22 ;.


Publications — IRIC mai 2, 2017

Defining the role of the RSK isoforms in cancer.

Houles T, Roux PP
Semin. Cancer Biol. 2017-05-02 ;.


Publications — IRIC avril 18, 2017

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling.

Beautrait A, Paradis JS, Zimmerman B, Giubilaro J, Nikolajev L, Armando S, Kobayashi H, Yamani L, Namkung Y, Heydenreich FM, Khoury E, Audet M, Roux PP, Veprintsev DB, Laporte SA, Bouvier M
Nat Commun 2017-04-18 ;8:15054.


Publications — IRIC avril 1, 2017

Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylate Gab2 To Promote a Negative-Feedback Loop That Attenuates Phosphoinositide 3-Kinase/Akt Signaling.

Zhang X, Lavoie G, Méant A, Aubert L, Cargnello M, Haman A, Hoang T, Roux PP
Mol. Cell. Biol. 2017-04-01 ;37( 7 ):.


Publications — IRIC février 1, 2017

Proteomics Screen Identifies Class I Rab11 Family Interacting Proteins as Key Regulators of Cytokinesis.

Laflamme C, Galan JA, Ben El Kadhi K, Méant A, Zeledon C, Carréno S, Roux PP, Emery G
Mol. Cell. Biol. 2017-02-01 ;37( 3 ):.


Publications — IRIC décembre 1, 2016

High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.

Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hébert J, Sauvageau G, Kwok B, Roux PP, Hoang T
J. Clin. Invest. 2016-12-01 ;126( 12 ):4569-4584.


Publications — IRIC août 31, 2015

Receptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.

Paradis JS, Ly S, Blondel-Tepaz É, Galan JA, Beautrait A, Scott MG, Enslen H, Marullo S, Roux PP, Bouvier M
Proc. Natl. Acad. Sci. U.S.A. 2015-08-31 ;.


Publications — IRIC juillet 1, 2015

Translational control by oncogenic signaling pathways.

Gao B, Roux PP
Biochim. Biophys. Acta 2015-07-01 ;1849( 7 ):753-765.


Publications — IRIC mars 24, 2015

Effect of the transient pharmacological inhibition of mapk3/1 pathway on ovulation in mice.

Siddappa D, Beaulieu É, Gévry N, Roux PP, Bordignon V, Duggavathi R
PLoS ONE 2015-03-24 ;10( 3 ):e0119387.


Publications — IRIC mars 1, 2015

The expanding role of mTOR in cancer cell growth and proliferation.

Cargnello M, Tcherkezian J, Roux PP
Mutagenesis 2015-03-01 ;30( 2 ):169-176.


Publications — IRIC février 2, 2015

Regulation of global and specific mRNA translation by the mTOR signaling pathway.

Nandagopal N, Roux PP
Translation (Austin) 2015-02-02 ;3( 1 ):e983402.


Publications — IRIC juillet 22, 2014

Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.

Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschke GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP
Proc. Natl. Acad. Sci. U.S.A. 2014-07-22 ;111( 29 ):E2918-27.


Publications — IRIC juillet 21, 2014

Cellular control of cortical actin nucleation.

Bovellan M, Romeo Y, Biro M, Boden A, Chugh P, Yonis A, Vaghela M, Fritzsche M, Moulding D, Thorogate R, Jégou A, Thrasher AJ, Romet-Lemonne G, Roux PP, Paluch EK, Charras G
Curr. Biol. 2014-07-21 ;24( 14 ):1628-35.


Publications — IRIC juillet 17, 2014

A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells.

Lima-Fernandes E, Misticone S, Boularan C, Paradis JS, Enslen H, Roux PP, Bouvier M, Baillie GS, Marullo S, Scott MG
Nat Commun 2014-07-17 ;5:4431.


Publications — IRIC juillet 1, 2014

Mechanistic target of rapamycin (MTOR) signaling during ovulation in mice.

Siddappa D, Kalaiselvanraja A, Bordignon V, Dupuis L, Gasperin BG, Roux PP, Duggavathi R
Mol. Reprod. Dev. 2014-07-01 ;81( 7 ):655-65.


Publications — IRIC juin 5, 2014

Mutations in DOCK7 in Individuals with Epileptic Encephalopathy and Cortical Blindness.

Perrault I, Hamdan FF, Rio M, Capo-Chichi JM, Boddaert N, Décarie JC, Maranda B, Nabbout R, Sylvain M, Lortie A, Roux PP, Rossignol E, Gérard X, Barcia G, Berquin P, Munnich A, Rouleau GA, Kaplan J, Rozet JM, Michaud JL
Am. J. Hum. Genet. 2014-06-05 ;94( 6 ):891-7.


Publications — IRIC avril 1, 2014

Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1.

Shin S, Wolgamott L, Tcherkezian J, Vallabhapurapu S, Yu Y, Roux PP, Yoon SO
Oncogene 2014-04-01 ;33( 13 ):1690-9.


Publications — IRIC février 15, 2014

Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5’TOP mRNA translation.

Tcherkezian J, Cargnello M, Romeo Y, Huttlin EL, Lavoie G, Gygi SP, Roux PP
Genes Dev. 2014-02-15 ;28( 4 ):357-71.


Publications — IRIC janvier 1, 2014

Casein Kinase 1{varepsilon} Promotes Cell Proliferation by Regulating mRNA Translation.

Shin S, Wolgamott L, Roux PP, Yoon SO
Cancer Res. 2014-01-01 ;74( 1 ):201-11.


Publications — IRIC décembre 1, 2013

The Coming of Age of Phosphoproteomics–from Large Data Sets to Inference of Protein Functions.

Roux PP, Thibault P
Mol. Cell Proteomics 2013-12-01 ;12( 12 ):3453-64.


Publications — IRIC novembre 1, 2013

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.

Biro M, Romeo Y, Kroschwald S, Bovellan M, Boden A, Tcherkezian J, Roux PP, Charras G, Paluch EK
Cytoskeleton (Hoboken) 2013-11-01 ;70( 11 ):741-54.


Publications — IRIC novembre 1, 2013

Disruption of TBC1D7, a subunit of the TSC1-TSC2 protein complex, in intellectual disability and megalencephaly.

Capo-Chichi JM, Tcherkezian J, Hamdan FF, Décarie JC, Dobrzeniecka S, Patry L, Nadon MA, Mucha BE, Major P, Shevell M, Bencheikh BO, Joober R, Samuels ME, Rouleau GA, Roux PP, Michaud JL
J. Med. Genet. 2013-11-01 ;50( 11 ):740-4.


Publications — IRIC octobre 25, 2013

Insulin Activates RSK (p90 Ribosomal S6 Kinase) to Trigger a New Negative Feedback Loop That Regulates Insulin Signaling for Glucose Metabolism.

Smadja-Lamère N, Shum M, Déléris P, Roux PP, Abe J, Marette A
J. Biol. Chem. 2013-10-25 ;288( 43 ):31165-76.


Publications — IRIC octobre 7, 2013

Rapamycin Resistance: mTORC1 Substrates Hold Some of the Answers.

Yoon SO, Roux PP
Curr. Biol. 2013-10-07 ;23( 19 ):R880-3.

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Philippe P. Roux
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