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  • September 30, 2022

    Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor.

    Fink EA, Xu J, Hübner H, Braz JM, Seemann P, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM, Tolmachova NA, Moroz YS, Huang XP, Kalyanaraman C, Gahbauer S, Chen G, Liu Z, Jacobson MP, Irwin JJ, Bouvier M, Du Y, Shoichet BK, Basbaum AI, Gmeiner P
    Science 2022-09-30 ;377( 6614 ):eabn7065

  • September 22, 2022

    From a Cone Snail Toxin to a Competitive MC4R Antagonist.

    Reynaud S, Laurin SA, Ciolek J, Barbe P, Van Baelen AC, Susset M, Blondel F, Ghazarian M, Boeri J, Vanden Driessche M, Upert G, Mourier G, Kessler P, Konnert L, Beroud R, Keck M, Servent D, Bouvier M, Gilles N
    J Med Chem 2022-09-22 ;65( 18 ):12084-12094

  • September 21, 2022

    Unorthodox PCNA Binding by Chromatin Assembly Factor 1.

    Gopinathan Nair A, Rabas N, Lejon S, Homiski C, Osborne MJ, Cyr N, Sverzhinsky A, Melendy T, Pascal JM, Laue ED, Borden K, Omichinski JG, Verreault A
    Int J Mol Sci 2022-09-21 ;23( 19 ):

  • September 16, 2022

    Two types of human TCR differentially regulate reactivity to self and non-self antigens.

    Trofimov A, Brouillard P, Larouche JD, Séguin J, Laverdure JP, Brasey A, Ehx G, Roy DC, Busque L, Lachance S, Lemieux S, Perreault C
    iScience 2022-09-16 ;25( 9 ):104968

  • September 14, 2022

    PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development.

    Zhao X, Bartholdy B, Yamamoto Y, Evans EK, Alberich-Jordà M, Staber PB, Benoukraf T, Zhang P, Zhang J, Trinh BQ, Crispino JD, Hoang T, Bassal MA, Tenen DG
    Commun Biol 2022-09-14 ;5( 1 ):961

  • September 13, 2022

    Unified gene expression signature of novel NPM1 exon 5 mutations in acute myeloid leukemia.

    Lisi V, Blanchard E, Vladovsky M, Audemard E, Ferghaly A, Lemieux S, Hébert J, Sauvageau G, Lavallée VP
    Blood Adv 2022-09-13 ;6( 17 ):5160-5164

  • September 6, 2022

    3D chromatin remodeling potentiates transcriptional programs driving cell invasion.

    Lebeau B, Jangal M, Zhao T, Wong CK, Wong N, Cañedo EC, Hébert S, Aguilar-Mahecha A, Chabot C, Buchanan M, Catterall R, McCaffrey L, Deblois G, Kleinman C, Park M, Basik M, Witcher M
    Proc Natl Acad Sci U S A 2022-09-06 ;119( 36 ):e2203452119

  • September 6, 2022

    Proteogenomics and Differential Ion Mobility Enable the Exploration of the Mutational Landscape in Colon Cancer Cells.

    Wu Z, Bonneil E, Belford M, Boeser C, Ruiz Cuevas MV, Lemieux S, Dunyach JJ, Thibault P
    Anal Chem 2022-09-06 ;94( 35 ):12086-12094

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