Pierre Thibault’s laboratory uses quantitative proteomics and bioanalytical mass spectrometry to study the molecular mechanisms and post-translational modifications that control the function, dynamics, and localization of key proteins involved in immunity and cell signaling, particularly in the context of cancer.

Research theme

The research carried out by Pierre Thibault’s team aims to develop and apply new technologies in the proteomics and cell biology fields. Part of a multidisciplinary research framework bringing together bioanalytical chemistry, protein chemistry, biochemistry and cell biology, these tools provide a better understanding of the molecular mechanisms and post-translational modifications regulating the protein functions and translocations involved in immunity and signalling in cancer cells.

Research objectives

Pierre Thibault and his team have developed strategies to identify and quantify proteins and their modifications (including phosphorylation, acetylation, SUMOylation, and ubiquitylation), which are now being used in several programs aimed at elucidating complex biological mechanisms. His team has also developed innovative approaches in immunopeptidomics to characterize peptides presented by major histocompatibility complexes of class I and II, including mutated peptides or those derived from non-coding regions, opening up access to new repertoires of antigens relevant to immunotherapy.

Finally, the group’s advances have contributed significantly to the development of ion mobility and its integration into mass spectrometry. By continually pushing the boundaries of analytical technologies, the laboratory aims to identify therapeutic targets and accelerate the development of personalized medicine and immunotherapy approaches.