Pierre Thibault’s laboratory uses quantitative proteomics and bioanalytical mass spectrometry expertise to study the molecular mechanisms and the post-translational modifications that regulate the function of proteins involved in immunity and signalling in cells.
The research carried out by Pierre Thibault’s team aims to develop and apply new technologies in the proteomics and cell biology fields. Part of a multidisciplinary research framework bringing together bioanalytical chemistry, protein chemistry, biochemistry and cell biology, these tools provide a better understanding of the molecular mechanisms and post-translational modifications regulating the protein functions and translocations involved in immunity and signalling in cancer cells.
Pierre Thibault and his team developed new approaches in proteomics to identify and qualify proteins and their post-translational modifications (phosphorylation, acetylation, sumoylation, ubiquitylation) currently being used in various research programs to elucidate several complex biological mechanisms. His team also developed innovative methods for identifying and quantifying peptides presented by the class I major histocompatibility complex, including peptides that carry mutations or come from non-coding regions.
Along with developing new methods for the analysis of proteins and their modifications, the advances made by the group have also greatly contributed to the development of ionic mobility and its use in mass spectrometry.
While pushing the boundaries of mass spectrometry and proteomics technology, the main objective of the research carried out in Pierre Thibault’s laboratory is to identify therapeutic targets to counter certain aberrant activities of cancer cells and to facilitate the development of personalized medicine and immunotherapy.