Katherine Borden earned her Ph.D. in Molecular Biology from Yale University where she worked under the direction of Fred Richards. She then completed two postdoctoral fellowships in the United Kingdom at the National Institute for Medical Research (now the Crick Institute) and the Imperical Cancer Research Fund (now Cancer Research UK), under the supervision of Andrew Lane and Paul Freemont & Ellen Solomon, where she developed expertise in structural, molecular, cell and cancer biology.
After working as a Professor at Dalhousie University, then at the Mount Sinai School of Medicine in New York, she joined the IRIC team in 2004.